Thursday, March 31, 2005

Acrodermatitis enteropathica

Acrodermatitis enteropathica is an autosomal recessive disease due to a partial disorder of intestinal zinc uptake. Signs usually appear within the first months of life, with a characteristic cutaneous rash that is symmetrical, located around the body orifices, behind the ears, and on hands, feet, and head. Zinc deficiency may be due to inadequate intake, malabsorption, excessive loss, or a combination of these factors. If treated early, most of the symptoms are reversible and usually leave no sequelae. Untreated patients usually die within the first few years of life. They have severe growth retardation, dermatitis, alopecia, secondary bacterial and fungal infections, and neurological and behavioral changes. Treatment is essentially with dietary or I/V supplementation. Dietary supplementation with 2 – 3 times the recommended daily allowance, 30 – 55 mg/day of elemental zinc dramatically reverses the manifestations within hours to days. View Images

1 comment:

Shahbaz A.Janjua MD said...

Dear Dr.Arfan, I am so glad that you could create this post. I have created a hyperlink for the post to the global skin atlas. Please check if it is working fine. Nice images with periorificial and acral dermatitis and desquamation. How long do we need to continue the zinc supplementation in such cases?